Where squamous cell carcinoma originates

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It usually shows up on areas of the skin that are exposed to the sun, such as the face, ears, lips, arms, legs, and tops of hands, but it can also more rarely appear on areas not exposed to the sun, including the lower lip, genitals, lungs, and esophagus.

How does squamous cell carcinoma form?

Squamous cell carcinoma occurs when squamous cells begin to grow uncontrollably in the top layers of the skin, known as the epidermis.

This uncontrolled growth is usually a result of cellular damage often caused by chronic exposure to UV rays over time. This means that people who use tanning beds or who have spent a lot of time outdoors unprotected are at a much higher risk of developing squamous cell carcinoma as well as those with pale skin types.

Cellular damage can also more rarely be caused by other factors such as exposure to toxic substances or a weakened immune system. This puts people who have a history of actinic keratosis, those who have had some form of the human papillomavirus or have been badly burned in the past at a higher risk for developing the cancer as well.

What does a normal mole look like?

Where does squamous cell carcinoma form?

Researchers have been working to determine which cells trigger squamous cell carcinoma to form. Some evidence points to hair follicle stem cells as the origin point. Looking even closer, within these cells, researchers from UCLA discovered that the mother stem cells can develop the cancer while the progeny cells cannot.

This distinction between two different types of cells in the skin is providing researchers with new research targets. Looking into why one cell can develop the cancer and the other cannot is a potential avenue to treatments that may be able to prevent the cancer before it starts.

If you have any suspicions about a mole, spot or growth, have it checked out as soon as possible. 

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"I think it probably saved my life"
Seonaid Sichel
United Kingdom
"SkinVision gave me the confidence to go and ask the doctor"
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United Kingdom
"The melanoma could have been on my arm for years"
Andrew Bartlett
United Kingdom
"I’m now under strict watch"
Barry Joblin
New Zealand

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